Bioactive Small Molecules
![Medchemexpress LLC 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | 1431985-92-0 | 99.7% | 10MM 1ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230662.png-250.jpg)
Medchemexpress LLC 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | 1431985-92-0 | 99.7% | 10MM 1ML
3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | 1431985-92-0 | 99.7% | 10MM 1ML
Medchemexpress LLC 1,6-Anhydro-β-D-mannopyranose | 14168-65-1 | MFCD00069698 | 99.2% | 162.14 | C6H10O5 | 250MG
Mannosan (1,6-anhydro-β-D-mannopyranose) is an anhydro sugar reagent supplied as a white to off-white solid for use in glycobiology and carbohydrate research. It is provided in multiple laboratory pack sizes for analytical and preparative work, and has formula C6H10O5 and molecular weight 162.14.
- Purity determined at 99.18%.
- Molecular formula C6H10O5 and molecular weight 162.14.
- Available in small laboratory pack sizes suitable for research use.
- White to off-white solid, easy to handle and store.
- Used as a reagent in glycobiology and carbohydrate chemistry applications.
![Medchemexpress LLC 1-[4-[5-carbamoyl-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazol-1-yl]butyl]-2-[(2-ethyl... | 2138300-40-8 | 99.5% | 678.74 g·mol⁻¹ | C34H38N12O4 | 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000235629.png-250.jpg)
Medchemexpress LLC 1-[4-[5-carbamoyl-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazol-1-yl]butyl]-2-[(2-ethyl... | 2138300-40-8 | 99.5% | 678.74 g·mol⁻¹ | C34H38N12O4 | 1MG
STING agonist-4 is a small-molecule agonist of the stimulator of interferon genes (STING) receptor used as a research reagent to modulate innate immune signaling. It exhibits nanomolar potency and is typically used in in vitro pathway activation studies and preclinical immunology research.
- Potent STING agonist with IC50 ≈ 20 nM.
- Chemical formula C34H38N12O4 and molecular weight 678.74 g·mol⁻¹.
- High reported purity suitable for research use (≈99.5%).
- Offered in small pack sizes for experimental flexibility.
- Applicable for in vitro immune signaling and preclinical studies.
Medchemexpress LLC PKC-theta inhibitor 1 | 1160501-81-4 | 99.7% | 348.32 g·mol⁻¹ | C17H15F3N4O | 5MG
PKC-theta inhibitor 1 is an orally active, selective ATP-competitive inhibitor of protein kinase C theta (PKCθ) used in biochemical and cellular research to probe PKCθ-mediated signaling pathways. It is a small-molecule research reagent with reported high potency and listed high purity.
- Selective ATP-competitive inhibition of PKCθ for target-specific studies.
- High potency with reported Ki ≈ 6 nM.
- High purity (99.7%) suitable for biochemical assays.
- Characterized small molecule with formula C17H15F3N4O and molecular weight 348.32 g·mol⁻¹.
- Available in multiple research pack sizes for assay flexibility.
Medchemexpress LLC Ceftobiprole medocaril sodium | 252188-71-9 | 95.7% | 712.64 g/mol | C26H25N8NaO11S2 | 10 MG
Ceftobiprole medocaril sodium is the parenteral prodrug (sodium salt) of ceftobiprole, a pyrrolidinone cephalosporin antibiotic supplied for research use. It displays broad-spectrum in vitro antibacterial activity and is provided as an off-white to light yellow solid for biochemical and antimicrobial studies.
- Parenteral prodrug sodium salt suitable for in vitro research.
- Broad-spectrum activity including MRSA and penicillin-resistant streptococci.
- Purity approximately 95.7% with solid appearance.
- Molecular weight 712.64 g/mol; formula C26H25N8NaO11S2.
- Recommended storage: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC Thal-sns-032 | 2139287-33-3 | >98.0% | 869.02 g·mol⁻¹ | C40H52N8O10S2 | 1MG
THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of the CDK-binding ligand SNS-032 linked to a thalidomide-derived cereblon (CRBN) E3 ligase ligand. It promotes CRBN-dependent ubiquitination and proteasomal degradation of CDK9 and is supplied as a high-purity research compound for in vitro target degradation and mechanistic studies.
- Selective CDK9 degradation via cereblon recruitment.
- Reported potency with EC50 ≈ 4 nM in cell-based assays.
- High purity (≥98% by HPLC) suitable for research use.
- Molecular weight 869.02 g·mol⁻¹ and defined molecular formula.
- Designed for use in mechanistic and pharmacology studies of targeted protein degradation.
![Medchemexpress LLC 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | 1206711-16-1 | >98.0% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231466.png-250.jpg)
Medchemexpress LLC 4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | 1206711-16-1 | >98.0% | 5 MG
DMH-1 is a small-molecule inhibitor of bone morphogenetic protein (BMP) type I receptors used in research to probe BMP/TGF-β signaling pathways. It provides potent, selective inhibition of ALK family kinases and is supplied as a high-purity analytical standard.
- Selective BMP type I receptor inhibitor with low-nanomolar activity.
- Reported IC50s: ALK1 27 nM; ALK2 107.9 nM; ALK3 <5 nM; ALK6 47.6 nM.
- Molecular formula C24H20N4O and molecular weight 380.44 g/mol.
- Purity ≥98% (HPLC).
- CAS number 1206711-16-1 for substance identification.
Medchemexpress LLC Disopyramide phosphate | 22059-60-5 | MFCD00069254 | 99.9% | 437.47 | C21H32N3O5P | 100MG
Disopyramide phosphate is the phosphate salt of disopyramide, a class IA antiarrhythmic used in research to study cardiac electrophysiology. It blocks the fast inward sodium current, prolongs cardiac action potentials, inhibits hERG-encoded potassium channels, and exhibits negative inotropic effects. Supplied as a high-purity reference standard, it is intended for in vitro pharmacology and electrophysiology applications.
- High purity suitable for analytical and reference use.
- Available in multiple pack sizes including 100 mg for experimental flexibility.
- Chemical formula C21H32N3O5P and molecular weight 437.47 g/mol for accurate dosing and calculations.
- Relevant for sodium channel and cardiac action potential research.
- Solid form enables straightforward storage and handling.
Medchemexpress LLC Brensocatib | 1802148-05-5 | 99.9% | 420.46 | C23H24N4O4 | 100 MG
Brensocatib is an oral dipeptidyl peptidase 1 (DPP1) inhibitor used in preclinical research to modulate neutrophil serine protease activation. The compound is supplied as a characterized research chemical with documented physicochemical properties and recommended storage conditions.
- Selective DPP1 inhibition for mechanistic and pharmacology studies.
- Potent activity reported across species, supporting translational research.
- Characterized chemical identity with CAS 1802148-05-5 and formula C23H24N4O4.
- Available in multiple quantities to support assay development and in vitro testing.
- Storage recommendations provided for powder and solution forms to preserve stability.
Medchemexpress LLC DBCO-NHS ester 2 5mg | 1384870-47-6 | 430.45 g/mol | C25H22N2O5 | 5 MG
DBCO-NHS ester 2 is an amine-reactive DBCO-derived N-hydroxysuccinimide (NHS) ester used as a click-chemistry linker for strain-promoted alkyne-azide cycloaddition (SPAAC). It enables copper-free conjugation to azide-containing partners and is commonly used in bioconjugation and linker synthesis workflows.
- Enables copper-free SPAAC with azide-containing partners.
- Reacts with primary amines via NHS ester chemistry to form stable amide bonds.
- Useful for linker and probe synthesis in antibody-drug conjugate and labeling applications.
- Provided in small research-scale masses for convenient handling and formulation.
Medchemexpress LLC N-hydroxy-7-(naphthalen-2-ylsulfanyl)heptanamide | 926908-04-5 | MFCD10568146 | 99.8% | 303.42 g/mol | C17H21NO2S | 25 MG
HNHA is a small-molecule histone deacetylase (HDAC) inhibitor used for biomedical research. It inhibits HDACs with reported IC50 around 100 nM, arrests the cell cycle at G1/S via p21 induction, and has demonstrated antitumor and anti-angiogenic activity in preclinical studies.
- Potent HDAC inhibitor with reported IC50 of ~100 nM.
- High purity, listed as 99.76% on the product page.
- Molecular formula C17H21NO2S and molecular weight 303.42 g/mol.
- Provided in small research quantities, including 25 mg packages.
- For research use only; not for human or diagnostic use.
Medchemexpress LLC Arv-771 | 1949837-12-0 | MFCD30738017 | >95.0% | 986.64 g/mol | C49H60ClN9O7S2 | 1 ML
ARV-771 is a PROTAC BET degrader used in cell biology and cancer research to induce targeted degradation of BET family proteins. The compound is supplied as powder or as a prepared solution, is highly soluble in DMSO, and is provided with manufacturer guidance for preparing millimolar stock solutions. Molecular formula C49H60ClN9O7S2; molecular weight 986.64 g/mol; CAS 1949837-12-0.
- Proteolysis-targeting chimera mechanism for BET degradation
- Available as powder or in solvent for experimental flexibility
- High solubility in DMSO (≥50 mg/mL) enables concentrated stocks
- Stock preparation guidance supplied for 1, 5, and 10 mM concentrations
- Storage recommendations for powder and in-solution forms
- Formulation examples provided for in vivo dosing vehicles